Targeted 1H NMR metabolomics and immunological phenotyping of human fresh blood and serum samples discriminate between healthy individuals and inflammatory bowel disease patients treated with anti-TNF

针对人类新鲜血液和血清样本的靶向 1H NMR 代谢组学和免疫表型分析可区分健康个体和接受抗 TNF 治疗的炎症性肠病患者

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作者:Sara Notararigo, Manuel Martín-Pastor, Juan E Viñuela-Roldán, Adriano Quiroga, J Enrique Dominguez-Munoz, Manuel Barreiro-de Acosta

Key messages

NMR metabolomics is a non-invasive tool that could be implemented in the normal clinical practice for IBD to assess beneficial effect of the treatment. NMR metabolomics is a useful tool for precision medicine, in order to sew a specific treatment to a specific group of patients. Finding predictors of response to IFX would be desirable to select patients affected by IBD. Immunological status of inflammations correlates with NMR metabolomics biomarkers.

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