Short Communication: Lack of Effect of Maraviroc Intensification on Blood and Gut Reservoir

简短交流:马拉维若强化治疗对血液和肠道储库缺乏影响

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作者:Juan Tiraboschi, Shuvra Ray, Kemal Patel, Matt Pace, Prabhjeet Phalora, Nicola Robinson, Emily Hopkins, Jodi Meyerowitz, Yanzhong Wang, Olubanke Davies, Christine Mant, John Cason, Steve Kaye, Jeremy Sanderson, Sarah Fidler, Paul Klenerman, John Frater, Julie Fox

Abstract

We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term antiretroviral therapy was not associated with improvements in HIV-related morbidity, HIV reservoir, microbial translocation, immune activation, or immune exhaustion in either gut or peripheral blood. The measurement of reservoir in both gut and blood longitudinally contributes to a paucity of data in the area.

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