Abstract
INTRODUCTION: Multicentric giant cell tumor of bone is extremely rare, accounting for less than 1% of all giant cell tumor of bone (GCTB) cases. Metachronous multicentric GCTB is even rarer. CASE PRESENTATION: We present a rare case of metachronous multicentric giant cell tumor of bone (GCTB) in a 27-year-old male, in whom three distinct lesions developed sequentially over a 10-year period: first in the right distal femur, followed by the proximal femur, and later the proximal tibia. To address progressive disease and prosthetic complications, the patient underwent revision of the mega-prosthesis combined with adjuvant denosumab therapy, followed by curettage of the subsequently emerging tibial lesion. CONCLUSION: This case illustrates the sequential development of multiple GCTB lesions and the importance of combined surgical reconstruction and denosumab therapy in long-term management.