Abstract
INTRODUCTION: Systemic inflammation is increasingly recognized for its role in cancer prognosis. Inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammation index (SII) are emerging as relevant factors in oncology. This study evaluates their associations with established prognostic classifications in prostate cancer (PCa): the Cambridge Prognostic Groups (CPG) and the International Society of Urological Pathology (ISUP) grading system. METHODS: A retrospective cohort study was conducted on 272 prostate cancer patients using systematically collected clinical data. We calculated and analyzed NLR, PLR, and SII concerning CPG and ISUP scores. RESULTS: Statistically significant relationships were found between NLR, SII, and prognostic classifications. PLR did not demonstrate any significant association. CONCLUSION: NLR and SII may be helpful to prognostic factors in PCa, particularly in outpatient settings. However, further multi-center validation and establishing standardized cut-off values are necessary.