Abstract
PURPOSE: The blur introduced by breathing motion degrades the diagnostic accuracy of whole-body F-18 fluorodeoxyglucose positron emission tomography-computed tomography ((18)F-FDG PET-CT) in lesions adjacent to the diaphragm by increasing the apparent size and by decreasing their metabolic activity. This study aims to evaluate the efficacy of motion correction by four-dimensional phase-based respiratory-gated (RG) (18)F-FDG PET-CT in improving metabolic parameters of lesions adjacent to the diaphragm (especially in the lungs or liver). MATERIALS AND METHODS: Eighteen patients with known lung or liver lesions underwent conventional (18)F-FDG PET-CT and respiratory-gated PET-CT acquisition of the desired region using a pressure-sensing, phase-based respiratory-gating system. Maximum standardized uptake value (SUV(max)), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained for these lesions from gated and nongated PET-CT images for analysis. Furthermore, a visual analysis of lesions was done. STATISTICS: Statistical significance of the RG image parameters was assessed by the two-tailed paired Student's t test and confirmed with the robust nonparametric Wilcoxon's signed-rank test (two-tailed asymptotic). RESULTS: There was an overall significant increase in SUV(max) (P 0.001) in all gating methods with a percentage increase maximum of about 18.13%. On gating methods, MTV decreased significantly (P = 0.001) than that of nongating method (maximum reduction of about 32.9%). There was a significant difference (P = 0.02) in TLG between gated and nongated methods. CONCLUSION: Motion correction with phase-based respiratory gating improves the diagnostic value of (18)F-FDG PET-CT imaging for lung and liver lesions by more accurate delineation of the lesion volume and quantitation of SUV and can thus impact staging, diagnosis as well as management in selected patients.