Conclusion
FD-PRP injection is effective in inducing neuroregeneration by increasing NGF and S100B expression.
Methods
Fifty-four male wistar rats aged 3 months randomly divided into 3 groups; negative control group (without nerve injury and without FD-PRP injection), positive control group (nerve injury but without FD-PRP injection) and treatment group (nerve injury and FD-PRP injection). Axonotmesis nerve injury created by clamping the infraorbital nerve for 15 s. Application of FD-PRP by injection technique. Examination of NGF and S100B expression was obtained by immunohistochemistry examination with monoclonal antibodies (anti-NGF and anti-S100B). Samples were taken on the 14th day and 21st day.
Results
Treatment group showed significant increase on both NGF and S100B compare to positive control (p = 0,000 and p = 0,000, respectively).