Abstract
Male and female mice with a dominant severe bone fragility disorder, osteogenesis imperfecta, and their wild-type littermates (FVB background) were challenged with a long-term (26 weeks) high-fat diet to evaluate the development of obesity and glucose intolerance. Here we present data for the measurements of body mass, the outcome of glucose tolerance tests during the long-term diet, as well as organ weights and bone phenotype at the end of the study. Interpretation of the data and further in-depth analysis can be found in the article "Male but not female mice with severe osteogenesis imperfecta are partially protected from high-fat diet-induced obesity." by Tauer JT, Boraschi-Diaz I, Al Rifai O, Rauch F, Ferron M, Komarova SV, published in Molecular Genetics and Metabolism. The data presented here demonstrate individual mouse outcomes of long-term diet experiments that can be reused for comparative studies of diet-induced changes in wild-type mice on different backgrounds and different mouse models of osteogenesis imperfecta.