The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis

啮齿动物肝脏发生断奶诱导退化并支持乳腺癌转移

阅读：4

作者：Erica T Goddard, Ryan C Hill, Travis Nemkov, Angelo D'Alessandro, Kirk C Hansen, Ori Maller, Solange Mongoue-Tchokote, Motomi Mori, Ann H Partridge, Virginia F Borges, Pepper Schedin

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2017

起止号：

2017 Feb;7(2):177-187.

doi：

10.1158/2159-8290.CD-16-0822

研究方向：

肿瘤

疾病类型：

乳腺癌

Significance

We find that patients with postpartum breast cancer are at elevated risk for liver metastasis. We identify a previously unrecognized biology, namely weaning-induced liver involution, that establishes a prometastatic microenvironment, and which may account in part for the poor prognosis of patients with postpartum breast cancer. Cancer Discov; 7(2); 177-87. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 115.

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