Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers

RasGAP 肿瘤抑制因子的缺失是管腔 B 型乳腺癌侵袭性的基础

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作者：Sarah Naomi Olsen, Ania Wronski, Zafira Castaño, Benjamin Dake, Clare Malone, Thomas De Raedt, Miriam Enos, Yoko S DeRose, Wenhui Zhou, Stephanie Guerra, Massimo Loda, Alana Welm, Ann H Partridge, Sandra S McAllister, Charlotte Kuperwasser, Karen Cichowski

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2017

起止号：

2017 Feb;7(2):202-217.

doi：

10.1158/2159-8290.CD-16-0520

方法学：

研究方向：

肿瘤

疾病类型：

乳腺癌

Significance

The lack of insight into mechanisms that underlie the aggressive behavior of luminal B breast cancers impairs treatment decisions and therapeutic advances. Here, we show that two RasGAP tumor suppressors are concomitantly suppressed in aggressive luminal B tumors and demonstrate that they drive metastasis by activating RAS and NF-κB. Cancer Discov; 7(2); 202-17. ©2016 AACR.See related commentary by Sears and Gray, p. 131This article is highlighted in the In This Issue feature, p. 115.

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