Abstract
OBJECTIVE: Emergence of antimicrobial resistance is a major public health problem worldwide, particularly in developing countries. The aim of this study was to determine the antimicrobial resistance pattern of Staphylococcus aureus isolate from different clinical specimens at University of Gondar comprehensive specialized hospital. This retrospective study used laboratory records of 25870 clinical specimens submitted for bacterial culture submitted to the microbiology laboratory of University of Gondar comprehensive specialized hospital for bacterial culture and sensitivity testing from July 2018 and June 2022. Records from specimens positive for Staphylococcus aureus isolates were included for analysis. RESULT: Of the total 25,870 samples culture records, 4653 (18%) were culture positive for bacteria. A total of 1057 S. aureus isolates were collected from clinical specimens such as: wound discharge (342; 32.4%), blood (312; 29.5%), cerebrospinal fluid (16; 1.5%), urine (21; 2%), other body fluids (71; 6.7%) and other discharge like ear discharge, eye discharge and vaginal discharge295; 28%). The prevalence of methicillin resistant S. aureus was 33.8% (233/698) and the overall prevalence of multi-drug resistant S. aureus out of 1057 S. aureus isolates was 36% (380/1057).