Abstract
Flexible wearable biosensors have emerged as a promising tool for tracking dynamic glycemic profiles of human body in diabetes management. However, it remains a challenge to balance the shrunken device space and multiple redundant sensing arrays for further advancement in miniaturization of multimodal sensors. Herein, this work proposes an entirely new optoelectronic hybrid multimodal optical fiber sensor which is composed of laser patterning of polydimethylsiloxane (PDMS) to form laser-induced graphene (LIG) as the interdigital electrodes, and a long period grating (LPG) prepared from an optical microfiber encapsulated into the PDMS modulated by periodical structure of LIG electrodes. This operation can simultaneously integrate two heterogeneous sensing mechanisms, optical and electrical, into a single sensor in a compact manner. Combining the LIG electrode with conductive hydrogel, a flexible glucose biosensor based on electrical mechanism is constructed by loading glucose oxidase into the hydrogel. Meanwhile, the microfiber LPG can also be served as a spectroscopically available sensor for biomechanical monitoring. Optical and electrical sensors can work simultaneously but independently of each other, particularly in the scene of wound healing for rat model and movement for human exercise. This platform represents a pivotal step toward multifunctional sensors that enable measurements of biomechanical information and glucose.