Follicular Lymphoma Microenvironment Characteristics Associated with Tumor Cell Mutations and MHC Class II Expression

滤泡性淋巴瘤微环境特征与肿瘤细胞突变和 MHC II 类表达相关

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作者：Guangchun Han #, Qing Deng #, Mario L Marques-Piubelli, Enyu Dai, Minghao Dang, Man Chun John Ma, Xubin Li, Haopeng Yang, Jared Henderson, Olga Kudryashova, Mark Meerson, Sergey Isaev, Nikita Kotlov, Krystle J Nomie, Alexander Bagaev, Edwin R Parra, Luisa M Solis Soto, Simrit Parmar, Fredrick B Hage

期刊：

Blood Cancer Discovery

影响因子：

11.500

时间：

2022

起止号：

2022 Sep 6;3(5):428-443.

doi：

10.1158/2643-3230.BCD-21-0075

研究方向：

肿瘤

疾病类型：

淋巴瘤

细胞类型：

肿瘤细胞

Significance

We have characterized the FL-infiltrating T cells, identified cytotoxic CD4 T cells as an important component that is associated with tumor cell-intrinsic characteristics, and identified sets of targetable immune checkpoints on T cells that differed from FLs with normal versus low MHC expression. See related commentary by Melnick, p. 374. This article is highlighted in the In This Issue feature, p. 369.

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