Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes

基因特征衍生的 IC50/EC50 反映了致病上游靶点和下游表型的效力

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作者：Steffen Renner, Christian Bergsdorf, Rochdi Bouhelal, Magdalena Koziczak-Holbro, Andrea Marco Amati, Valerie Techer-Etienne, Ludivine Flotte, Nicole Reymann, Karen Kapur, Sebastian Hoersch, Edward James Oakeley, Ansgar Schuffenhauer, Hanspeter Gubler, Eugen Lounkine, Pierre Farmer

期刊：

Scientific Reports

影响因子：

3.800

时间：

2020

起止号：

2020 Jun 15;10(1):9670.

doi：

10.1038/s41598-020-66533-5

研究方向：

信号转导

Methods

beta-adrenergic agonistic activity on cAMP generation (dedicated dataset generated for this study) and EGFR inhibitory effect on cancer cell viability. In both cases, potencies derived from multi-gene expression data were highly correlated with orthogonal potencies derived from cAMP and cell growth readouts, and superior to potencies derived from single individual genes. Based on our

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