Crossing the border: Replication fork adducts move to lysosomes for autophagic repair

In a recent study in Cell, Lascaux et al.(1) implicate TEX264 in the autophagy-driven resolution of nuclear topoisomerase 1 cleavage complexes (TOP1cc) in lysosomes, altering current concepts on the mechanism of action for clinically relevant doses of TOP1 inhibitors.