Abstract
Tissue-engineered electronic nerve interfaces use arrays of microelectrodes suspended in hydrogel scaffolds to form regenerative neuroelectronic interfaces. Although high signal-to-noise ratio recordings of action potentials have been achieved in chronic experiments, one shortcoming is that the hydrogel degradation was often insufficient, with a significant amount remaining that blocked some regeneration. Here we report on a new approach that uses a hollow TEENI that has no hydrogel to overcome these limitations and ensure a smoother degradation process and a more natural nerve healing. This evolution marks a significant step forward in the development of TEENI technology.