Transient stimulation of TRPV4-expressing keratinocytes promotes hair follicle regeneration in mice

Hair follicle telogen to anagen transition

Hair follicle telogen to anagen transition

Here, we show that a single intradermal injection of GSK1016790A is sufficient to induce telogen to anagen transition and hair follicle regeneration in mice by increasing the expression of the anagen-promoting growth factors and down-regulating the expression of growth factors that inhibit anagen. The action of GSK1016790A relies largely on the function of TRPV4 in skin and involves activation of downstream ERK signalling.