Abstract
OBJECTIVE: Prescription medication (PM) misuse and abuse is a major health problem globally, and a number of recent studies have focused on exploring social media as a resource for monitoring nonmedical PM use. Our objectives are to present a methodological review of social media-based PM abuse or misuse monitoring studies, and to propose a potential generalizable, data-centric processing pipeline for the curation of data from this resource. MATERIALS AND METHODS: We identified studies involving social media, PMs, and misuse or abuse (inclusion criteria) from Medline, Embase, Scopus, Web of Science, and Google Scholar. We categorized studies based on multiple characteristics including but not limited to data size; social media source(s); medications studied; and primary objectives, methods, and findings. RESULTS: A total of 39 studies met our inclusion criteria, with 31 (∼79.5%) published since 2015. Twitter has been the most popular resource, with Reddit and Instagram gaining popularity recently. Early studies focused mostly on manual, qualitative analyses, with a growing trend toward the use of data-centric methods involving natural language processing and machine learning. DISCUSSION: There is a paucity of standardized, data-centric frameworks for curating social media data for task-specific analyses and near real-time surveillance of nonmedical PM use. Many existing studies do not quantify human agreements for manual annotation tasks or take into account the presence of noise in data. CONCLUSION: The development of reproducible and standardized data-centric frameworks that build on the current state-of-the-art methods in data and text mining may enable effective utilization of social media data for understanding and monitoring nonmedical PM use.