Investigation of an Enterobacter hormaechei OXA-436 carbapenemase outbreak: when everything goes down the drain

对霍氏肠杆菌OXA-436碳青霉烯酶暴发的调查:当一切都付诸东流

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Abstract

Over a time period of 18 months an Enterobacter hormaechei sequence type (ST) 90, harboring a bla (OXA-436) carbapenemase gene, was isolated from seven patients at Odense University Hospital, Denmark. The patients were all from the same department, but there was no apparent direct epidemiological link. Whole genome sequencing (WGS) was performed on all clinical isolates as well as on a number of environmental samples including two E. hormaechei ST90 isolates carrying the bla (OXA-436) gene, which were isolated in samples from two shower drains at the department. These drains were suspected to be the source of the outbreak.

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