Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia

非退行性轻度认知障碍患者与临床前痴呆患者言语节奏差异的变化

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Abstract

This study explores several speech parameters related to mild cognitive impairment, as well as those that might be flagging the presence of an underlying neurodegenerative process. Speech is an excellent biomarker because it is not invasive and, what is more, its analysis is rapid and economical. Our aim has been to ascertain whether the typical speech patterns of people with Alzheimer's disease are also present during the disorder's preclinical stages. To do so, we shall be using a task that involves reading out aloud. This is followed by an analysis of the recordings, looking for the possible parameters differentiating between those older people with MCI and a high probability of developing dementia and those with MCI that will not do so. We found that the disease's most differentiating parameters prior to its onset involve changes in speech duration and an alteration in rhythm rate and intensity. These parameters seem to be related to the first difficulties in lexical access among older people with AD.

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