Abstract
Magnocellular oxytocin and vasopressin neurons of the hypothalamus project to the posterior pituitary where they secrete their peptide hormone signals directly into the bloodstream. Their large anatomically distinct secretory mechanisms provide a uniquely accessible system in which to unite experimental and modelling approaches in the investigation of how input signals and electrophysiological properties of neurons relate to physiological function. We describe how the mechanisms have been translated and assembled into a mathematical model representation that can explain and simulate the complex and highly non-linear stimulus-secretion coupling of these neurons, and how this model has been applied to further understand these systems.