Abstract
Angiosarcoma is a malignant neoplasm of endothelial cells of blood vessels, representing 2% of all sarcomas. The occurrence of angiosarcoma in the oral cavity is a rare. In general management includes resection and wide-field postoperative radiation therapy. The risk of local-regional failure and distant relapse is still a cause of worry. Herewith, a case of angiosarcoma of mandible in a female patient is presented, who presented with small, innocent-looking mass, which became a highly destructive malignant tumor within few days.