Abstract
Ovarian failure and permanent infertility occur in nearly all women of childbearing age who are treated with myeloablative conditioning and allogeneic stem cell transplantation (SCT).(,) Recently, highly immunosuppressive but reduced intensity conditioning regimens have enabled the engraftment of allogeneic cells and their resulting graft-versus-tumor effects.(–) However, the effect of reduced intensity allogeneic stem cell transplantation, or RIST, on the reproductive function of young women has not been examined. Here we report on two women who had successful pregnancies and childbirths after RIST for lymphoma.