Abstract
OBJECTIVE: To assess the diagnostic performance and calculate the optimal threshold for quantitative biomarkers to differentiate bone metastasis and benign bone marrow lesions using turbo spin echo (TSE) Dixon images with a 3.0 T scanner. MATERIALS AND METHODS: Each 100 patients diagnosed with bone metastases and variable benign bone marrow lesions on spine MRI were included retrospectively. Images included in-phase (IP), opposed-phase (OP), water images (WI), and fat images (FI) by the TSE Dixon technique with T1WI and T2WI using a 3.0 T scanner. Regions of interest (ROI) of the lesions were manually drawn by two musculoskeletal radiologists independently, and the average signal intensity was recorded. The signal reduction rate from IP to OP (%drop) and a fat fraction (%fat) were calculated. RESULTS: All biomarkers showed a significant difference between metastatic and benign lesions (P < 0.001). When comparing the AUCs, the %drop of T1WI had the highest AUC (0.934). Although the AUC of %fat from T2WI was significantly lower than that of other biomarkers, the %drop of T2WI was not significantly different from the %drop of T1WI (p = 0.339). The optimal threshold of %drop to differentiate metastatic and benign lesions was 22.0 in T1WI and 15.9 in T2WI. The inter-reader agreement was excellent for all biomarkers (0.82-0.86). CONCLUSION: While %drop of T1WI showed the highest diagnostic performance to differentiate bone metastasis from benign lesions, the %drop of T2WI showed a comparable ability using a threshold 15.9.