Abstract
BACKGROUND AND OBJECTIVE: Human 8-hydroxyguanine glycosylase (hOGG1) is one of the DNA repair genes, which can repair damaged DNA by specifically excising 8-dihydro-8-oxoguanine (8-OH-G). A considerable number of studies investigating hOGG1 Ser326Cys polymorphism were in relation to various cancers. However, the association of hOGG1 Ser326Cys polymorphism with risk of lung cancer is inconsistency. The aim of this study is to assess the association of hOGG1 Ser326Cys polymorphism with risk of lung cancer by conducting a meta-analysis. METHODS: To identify all studies that are qualified for meta-analysis, we conducted a computerized literature search of MEDLINE database (before November, 2010). Two investigators independently extracted the data and reached a consensus on all items. RESULTS: According to our search limits, twenty-two case-control studies, including 8,575 lung cancer cases and 9,484 controls, were selected for meta-analysis. Significant heterogeneity was found among those twenty-two case-control studies, when excluding two studies that were not accorded with Hard-Weinberg Equilibrium, the remains performed well homogeneity. Compared with Ser326 genotype, Cys326 genotype can significantly increase risk of lung cancer (OR=1.24, 95%CI: 1.10-1.39, P < 0.001), especially in Asian ethnic population and hospital population (OR=1.28, 95%CI: 1.11-1.49; OR=1.26, 95%CI: 1.09-1.46). CONCLUSIONS: The present study indicates that the hOGG1 Ser326Cys polymorphism is associated with risk of lung cancer, Cys326 genotype can significantly increase risk of lung cancer.