Abstract
BACKGROUND AND OBJECTIVE: It has been proven that video assited thoracoscopic surgery (VATS) achieved the same survival rates compared with traditional open chest operation in the treatment of early stage of lung cancer. but it is unclear if there is any difference of body inflammatory reaction between the two operation. The aim of this study is to investigate the changes of inflammatory state of thoracoscopic radical lobectomy in early peripheral lung cancer patients. METHODS: Senventy-one early peripheral lung cancer patients who have underwent radical lobectomy were divided into two groups based on the different operation method. The VATS group was treated by thoracoscopic lobectomy. The thoracotomy group was treated by traditional thoracotomy. Then the level of serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-10 at 1-day before operation and 3-day, 7-day postoperation were measured and compared between the two groups. RESULTS: No significant difference was found in the level of serum CRP, TNF-α, IL-6 and IL-10 before operation. Compared to the thoracotomy group, the level of serum CRP, TNF-α, IL-6 and IL-10 in the VATS group were significantly lower after operation. CONCLUSIONS: Compared with thoracotomy lobectomy, thoracoscopic lobectomy for early peripheral lung cancer patients is associated with lower inflammatory responses .