Abstract
BACKGROUND: Intracranial atherosclerotic disease (ICAD) is a common cause of posterior circulation acute ischemic stroke. We aimed to compare baseline characteristics, recanalization rates, and clinical outcomes in patients with acute basilar occlusion due to underlying ICAD to patients with other causes of occlusion. METHODS: The Trevo Registry (ClinicalTrials.gov Identifier: NCT02040259) was a prospective open-label mechanical thrombectomy registry that included 2008 patients from 76 sites across 12 countries. For a secondary analysis, we selected patients with isolated acute basilar occlusion. We then classified patients into 2 groups: patients with acute basilar artery occlusion due to ICAD (ICAD group) and patients with acute basilar occlusion due to another cause (non-ICAD group). RESULTS: We identified 90 subjects with acute basilar occlusion. According to stroke mechanism, there were 9 (10.0%) patients in the ICAD group and 81 (90.0%) in the non-ICAD group. There was a significant difference (P=0.001) in the lesion location between the 2 groups, with 60.5% of non-ICAD occlusions located in the distal region and no ICAD occlusions there. The 2 groups showed a significant difference (P=0.003) for rescue therapy with balloon angioplasty, with 33.3% in the ICAD group and 1.2% in the non-ICAD group, respectively. In a multivariable model adjusted for age, baseline National Institutes of Health Stroke Scale, and intravenous tissue-type plasminogen activator (tPA), the odds of 90-day death (odds ratio=4.6; P=0.10) were higher for atherosclerotic subjects. CONCLUSION: Acute basilar occlusions related to ICAD showed a similar good clinical outcome (modified Rankin scale (mRS) 0-2) and a tendency for a higher rate of 90-day mortality compared with non-ICAD occlusions.