Impact of varying air cavity on planning dosimetry for rectum patients treated on a 1.5 T hybrid MR-linac system

不同气腔对使用1.5T混合磁共振-直线加速器系统治疗直肠患者的计划剂量学的影响

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Abstract

PURPOSE: To investigate the dosimetric impact of magnetic (B) field on varying air cavities in rectum patients treated on the hybrid 1.5 T MR-linac. METHODS: Artificial air cavities of varying diameters (0.0, 1.0, 1.5, 2.0, 2.5, 3.0, and 5.0 cm) were created for four rectum patients (two prone and two supine). A total of 56 plans using a 7 MV flattening filter-free beam were generated with and without B-field. Reference intensity-modulated radiation therapy treatment plans without air cavity in the presence and absence of B-field were generated to a total dose of 45/50 Gy. The reference plans were copied and recalculated for the varying air cavities. D(95) (PTV(45) -PTV(50) ), D(95) (PTV(50) -aircavity), V(50) (PTV(50) -aircavity), D(max) (PTV(50) -aircavity), and V(110%) (PTV(50) -aircavity) were extracted for each patient. Annulus rings of 1-mm-diameter step size were generated for one of the air cavity plans (3.0 cm) for all four patients to determine D(max) (%) and V(110%) (cc) within each annulus. RESULTS: In the presence of B-field, hot spots at the cavity interface start to become visible at ~1 cm air cavity in both supine and prone positioning due to electron return effect (ERE). In the presence of B-field D(max) and V(110%) varied from 5523 ± 49 cGy and 0.09 ± 0.16 cc for 0 cm air cavity size to 6050 ± 109 cGy and 11.6 ± 6.7 cc for 5 cm air cavity size. The hot spots were located within 3 mm inside the rectal-air interface, where D(max) increased from 110.4 ± 0.5% without B-field to 119.2 ± 0.8 % with B-field. CONCLUSIONS: Air cavities inside rectum affects rectum plan dosimetry due ERE. Location and magnitude of hot spots are dependent on the size of the air cavity.

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