Abstract
….the findings of Gutierrez et al. (22) add more fuel to the ongoing controversy regarding the association of APOL1 G1/G2 risk status with cardiovascular outcome among African Americans. However, if we acknowledge that the APOL1 risk alleles may directly modify the circulating levels of small HDL and/or other factors and induce a proatherogenic state that precipitates CKD and cardiovascular complications, then we should begin to answer several questions ….