Abstract
PURPOSE: We test if differential artery-vein analysis can increase the performance of optical coherence tomography angiography (OCTA) detection and classification of sickle cell retinopathy (SCR). METHOD: This observational case series was conducted in a tertiary-retina practice. Color fundus and OCTA images were collected from 20 control and 48 SCR subjects. Fundus data were collected from fundus imaging devices, and SD-OCT and corresponding OCTA data were acquired using a spectral-domain OCT (SD-OCT) angiography system. For each patient, color fundus image-guided artery-vein classification was conducted in the OCTA image. Traditional mean blood vessel tortuosity (m-BVT) and mean blood vessel caliber (m-BVC) in OCTA images were quantified for control and SCR groups. Artery BVC (a-BVC), vein BVC (v-BVC), artery BVT (a-BVT), and vein BVT (v-BVT) were calculated; and then the artery-vein ratio of BVC (AVR-BVC) and artery-vein ratio of BVT (AVR-BVT) were quantified for comparative analysis. RESULTS: We evaluated 40 control and 85 SCR images in this study. The color fundus image-guided artery-vein classification had 97.02% accuracy for differentiating arteries and veins in OCTA. Differential artery-vein analysis provided significant improvement (P < 0.05) in detecting and classifying SCR stages compared to traditional mean blood vessel analysis. AVR-BVT and AVR-BVC showed significant (P < 0.001) correlation with SCR severity. CONCLUSIONS: Differential artery-vein analysis can significantly improve the performance of OCTA detection and classification of SCR. AVR-BVT is the most sensitive feature that can classify control and mild SCR. TRANSLATIONAL RELEVANCE: SCR and other retinovascular diseases result in changes to the caliber and tortuosity appearance of arteries and veins separately. Differential artery-vein analysis can improve the performance of SCR detection and stage classification.