G1 cyclins protect pluripotency

G1 细胞周期蛋白保护多能性

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作者:Julia Arand, Julien Sage

Abstract

G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.

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