Conclusion
uCysLT levels are significantly reduced after AT in non-obese children with moderate/severe OSA, suggesting that exaggerated leukotriene activity is mainly a consequence of OSA.
Objective
The main objective of the study was to compare preoperative to postoperative levels of urine-Cysteinyl leukotrienes (uCysLT) in children undergoing adenotonsillectomy (AT) for obstructive sleep apnea (OSA) in order to investigate whether exaggerated leukotriene activity is the cause or consequence of OSA.
Results
27 children fulfilled the criteria and underwent a post-operative PSG study with three exclusions for residual OSA (postop-AHI>2), so the study group consisted of 24 children (mean age: 5.7 ± 2.1 years). Mean preoperative and postoperative AHI was 10.96 ± 5.93 and 1.44 ± 0.56 respectively. Mean preop-uCysLT were 21.14 ± 4.65, while after AT they significantly reduced to 12.62 ± 2.67 (P < 0.01).