Tyrosyl-DNA-Phosphodiesterase 2 (TDP2) Repairs Cleavage Complexes of Topoisomerase II (Top2) Once Top2 Undergoes Proteolysis♦: Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

酪氨酰-DNA-磷酸二酯酶 2 (TDP2) 修复拓扑异构酶 II (Top2) 的裂解复合物，一旦 Top2 发生蛋白水解♦：拓扑异构酶 II (Top2) 的蛋白水解降解使得酪氨酰-DNA-磷酸二酯酶 2 (TDP2) 能够加工 Top2·DNA 和 Top2·RNA 共价复合物。