Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

缺乏 RB1 肿瘤抑制基因的细胞高度依赖 Aurora B 激酶来生存

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作者：Matthew G Oser, Raquel Fonseca, Abhishek A Chakraborty, Rachel Brough, Alexander Spektor, Rebecca B Jennings, Abdallah Flaifel, Jesse S Novak, Aditi Gulati, Elizabeth Buss, Scott T Younger, Samuel K McBrayer, Glenn S Cowley, Dennis M Bonal, Quang-De Nguyen, Laura Brulle-Soumare, Paula Taylor, Stefan

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2019

起止号：

2019 Feb;9(2):230-247.

doi：

10.1158/2159-8290.CD-18-0389

方法学：

Cell sorting、FCM

研究方向：

肿瘤

细胞类型：

其它细胞

Significance

SCLC is rarely associated with actionable protooncogene mutations. We did a CRISPR/Cas9-based screen that showed that RB1 -/- SCLC are hyperdependent on AURKB, likely because both genes control mitotic fidelity, and confirmed that Aurora B kinase inhibitors are efficacious against RB1 -/- SCLC tumors in mice at nontoxic doses.See related commentary by Dick and Li, p. 169.This article is highlighted in the In This Issue feature, p. 151.

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