Abstract
BACKGROUND: Pulse pressure (PP) and mean arterial pressure (MAP) are well-established markers of cardiovascular risk. In this study, we aimed to assess the temporal trend and associated factors of PP and MAP in Chinese children and adolescents. METHODS: From the China Health and Nutrition Survey 1991-2015, a total of 11,123 children and adolescents aged 7-17 years were included. Stratified analyses and generalized estimating equation (GEE) were conducted to compare the trends of PP and MAP by age and sex over two decades, along with the calculation of average relative increase (ARI). Moreover, multivariable linear regression was used to estimate the associated factors of PP and MAP. RESULTS: During 1991-2015, upward trends were observed in both PP and MAP levels, with ARI of 0.30 and 0.34%, respectively. PP was higher in boys [PP(1991) 33.9 mmHg (95%CI, 33.40-34.33) to PP(2015) 35.4 mmHg (34.74-36.15)] than in girls [PP(1991) 33.3 mmHg (32.83-33.72) to PP(2015) 34.3 mmHg (33.59-34.99)]. PP was also higher in participants aged 13-17 years [PP(1991) 36.1 mmHg (35.63-36.62) to PP(2015) 38.3 mmHg (37.35-39.21)] than in those aged 7-12 years [PP(1991) 31.5 mmHg (31.09-31.88) to PP(2015) 33.7 mmHg (33.16-34.30)]. Similar results were found in MAP. Participants with high economic status, general obesity and central obesity, were more likely to have wider PP (β (higheconomicstatus) = 0.60, 95% CI, 0.19-1.02; β (generalobesity) = 1.38, 0.87-1.89; β (centralobesity) = 1.34, 0.70-1.97; all P-values < 0.001) and higher MAP (β (higheconomicstatus) = 0.82, 0.38-1.26; β (generalobesity) = 2.88, 2.33-3.42; β (centralobesity) = 3.14, 2.47-3.80; all P-values < 0.001). Body mass index (BMI) and waist circumference (WC) were positively correlated with PP (β (BMI) = 0.18, 0.13-0.24; β (WC) = 0.10, 0.08-0.12; both P-values < 0.001) and MAP (β (BMI) = 0.43, 0.37-0.49; β (WC) = 0.20, 0.18-0.22; both P-values < 0.001). In addition, rural setting and glucose level were positively associated with PP (both P < 0.05), while north region residency, uric acid, and total cholesterol were found to be positively associated with MAP (all P < 0.05). CONCLUSION: PP and MAP levels have been increasing dramatically in Chinese children and adolescents over the last two decades. Age, sex, economic status, geographic factors, anthropometric and cardiometabolic factor were positively associated with PP and MAP in pediatric population.