Mixed Glioneural Tumors Mimicking Gliomas: Two Cases From a Tertiary Care Institute in South India and a Literature Review

混合性神经胶质瘤酷似神经胶质瘤:来自印度南部一家三级医疗机构的两例病例报告及文献综述

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Abstract

Glioneuronal tumours are rare neural neoplasms that show differentiation and are usually low-grade. Unlike gliomas, they do not require aggressive management, and diagnosing and differentiating between these two entities is crucial to determining the treatment paradigm of this disease. Surgery is the treatment of choice for glioneuronal tumours, and the role of adjuvant treatment still needs to be fleshed out. These two cases, involving a six-year-old female child and a 35-year-old male patient, highlight the need to be cautious while differentiating these entities from their equivalents with poorer prognoses. They both underwent surgery followed by adjuvant radiation, with subsequent neuroimaging at regular intervals. Both patients were devoid of neurological complaints at the time of follow-up. These cases and literature review delve into the minutiae of clinical manifestations, histopathological characteristics, various modalities of treatment, and treatment outcomes of glioneuromas.

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