Conclusion
These findings suggest that compound 7: could serve as a new lead for the development of novel synthetic compounds with enhanced anticancer activity.
Results
Compound 7: had the greatest cytotoxic effect (cytotoxic concentration, CC50=24 μM) and selectivity (MRC-9; CC50>100 μM; inactive) in the A549 cell line, and caused cells to arrest in the S phase of the cell cycle, loss of MMP and increased ROS production in a concentration-dependent manner.