Screening circulating proteins to identify biomarkers of fetal macrosomia

筛查循环蛋白以确定胎儿巨大症的生物标志物

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作者:Tess Cruickshank, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Alesia Harper, Tuong-Vi Nguyen, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Roxanne Hastie, Stephen Tong, Susan P Walker, Teresa M MacDonald

Objective

Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal traumatic injuries, and perinatal death. If macrosomia is diagnosed in the antenatal period, labour can be induced to decrease shoulder dystocia. But current clinical

Results

We did not identify any significant changes in the plasma concentrations of COBLL1, CSH1, HSD3B1, EGFL6, XAGE3, S100P, PAPPA-1, ERBB2 from women who subsequently delivered macrosomic neonates relative to control samples. Although we have not identified any potential biomarkers of fetal macrosomia, we have ruled out these particular eight protein candidates.

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