Glyphosate does not substitute for glycine in proteins of actively dividing mammalian cells

草甘膦不能替代活跃分裂哺乳动物细胞蛋白质中的甘氨酸

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作者:Michael N Antoniou, Armel Nicolas, Robin Mesnage, Martina Biserni, Francesco V Rao, Cristina Vazquez Martin

Results

Comparative statistical analysis of global proteome changes between glyphosate treated and non-treated samples did not show significant differences. Crucially, filtering of data to focus analysis on peptides potentially bearing glycine for glyphosate replacement revealed that the TMT reporter intensity pattern of all candidates showed conclusively that they are all false discoveries, with none displaying the expected TMT pattern for such a substitution. Thus, the assertion that glyphosate substitutes for glycine in protein polypeptide chains is incorrect.

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