Inflammation biomarkers in vaginal fluid and preterm delivery

阴道液中的炎症生物标志物和早产

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作者:Brandie D Taylor, Claudia B Holzman, Raina N Fichorova, Yan Tian, Nicole M Jones, Wenjiang Fu, Patricia K Senagore

Methods

At enrollment at 16-27 weeks gestation, vaginal fluid samples were collected from a swab and 15 eluted biomarkers were measured using the Meso Scale Discovery multiplex electrochemiluminescence platform. Associations of biomarkers with PTD were examined, according to clinical circumstance, week at delivery and presence/absence of HCA. Weighted logistic regression was used to determine odds ratios (OR) and 95% confidence intervals (CI) adjusted for race. Sensitivity and specificity were compared between individual and multiple biomarkers, identified by a bootstrapping method. Main

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