Altered eutopic endometrial T-regulatory and T-helper 17 lymphocyte ratio in women with unexplained subfertility

不明原因生育力低下女性的正常子宫内膜 T 调节细胞和 T 辅助细胞 17 淋巴细胞比率改变

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作者:Malavika K Adur, Andrea G Braundmeier-Fleming, Bruce A Lessey, Romana A Nowak

Conclusion

Patients with a high proinflammatory Th17 lymphocyte profile and low Treg:Th17 ratio in their eutopic endometrium during the secretory phase of their menstrual cycle are more likely to not conceive in subsequent cycles.

Results

Though Treg cells were not indicative of conception success in subsequent cycles, patients who maintained their subfertile (no conception) status were observed to have a higher Th17 cell count in their eutopic endometrium. The ratio of Treg:Th17 cell counts was significantly correlated to patient conception status as well. These trends stayed consistent irrespective of concurrent endometriosis.

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