Abstract
BACKGROUND: Dendritic fibromyxolipoma (DFML) represents a benign lipomatous tumor. Its rarity and distinctive morphology can lead to misinterpretation of other mesenchymal malignancies, which may result in unnecessary aggressive treatments. CASE PRESENTATION: A 39-year-old male presented with a left mammary mass that had been noticed 1 year earlier. Chest computed tomography identified a nodule characterized by fat density in the left mammary region. The initial clinical impression was gynecomastia. A local excision of the left mammary mass was subsequently performed. Histopathological analysis confirmed the diagnosis of DFML. Post-surgical follow-up over 38 months showed no recurrence. CONCLUSION: DFML is a benign lipomatous tumor with unique morphological features. Complete surgical excision typically leads to no recurrence. This report documents the first known instance of DFML in the mammary gland of a male patient. Furthermore, an analysis of 95 previously documented cases of DFML was conducted. It is strongly advocated that the World Health Organization reclassify DFML as a mucinous subtype of spindle cell lipoma. This reclassification would improve the understanding of DFML and help avoid unnecessary aggressive treatments due to misdiagnosis as a malignancy.