Abstract
BACKGROUND: Acute suppurative parotitis is common in primary Sjögren syndrome due to parotid gland dysfunction. Streptococcus gordonii is an aggressive pathogen but is rarely reported in acute suppurative parotitis. CASE SUMMARY: A 64-year-old woman with primary Sjögren syndrome, history of periodontitis, and recurrent parotid swelling developed acute suppurative parotitis from Streptococcus gordonii, quickly leading to sepsis. The pathogen was confirmed via pus and blood cultures, and effective antimicrobial treatment was initiated promptly, controlling the condition. CONCLUSION: This case highlights the rapid progression of Streptococcus gordonii-induced acute suppurative parotitis to sepsis, emphasizing the importance of primary Sjögren syndrome screening and managing periodontal infections in patients with recurrent parotid swelling.