When neuroglial tissue wanders: a unique case report of subpleural heterotopia in a triploid foetus and review of the literature

神经胶质组织游走:三倍体胎儿胸膜下异位症的独特病例报告及文献综述

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Abstract

Heterotopic occurrence of neuroglial tissue is an exceedingly rare phenomenon with unclear pathogenesis, often presenting as lesions outside the central nervous system (CNS). We report a unique case of heterotopic neuroglial tissue identified in the thoracic cavity of a fetus aborted at 14 weeks due to a suspected Dandy-Walker malformation. The fetus exhibited neuroglial tissue growth subpleurally, alongside a suspected Dandy-Walker malformation and ventricular septal defect. While theories such as vascular embolisation, aspiration, and aberrant migration attempt to explain such occurrences, the exact etiology remains elusive. Our case suggests a potential association between triploidy and neuroglial heterotopia, supporting the aberrant migration and differentiation theory.

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