Buckle up: Membrane tension drives lamellipodial network compression and adhesion deposition

系好安全带:膜张力驱动片状伪足网络压缩和粘附沉积

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Abstract

Whether to spread on a surface or to crawl, cells must apply traction forces to the underlying substrate via adhesion complexes. In this issue, Pontes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201611117) shed new light on how the interplay among membrane tension, the lamellipodial actin network, and adhesions coordinate the dynamics of spreading fibroblasts.

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