Risk factors for COVID-19-associated mucormycosis (CAM): A case-control study

COVID-19相关毛霉菌病(CAM)的危险因素:一项病例对照研究

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Abstract

INTRODUCTION: Mucormycosis, a rare but serious fungal infection, surged during the second wave of the COVID-19 pandemic. Despite various proposed causative factors, published data are limited. This study aimed to identify risk factors for COVID-19-associated mucormycosis. METHODS: A case-control study was conducted in the Nagpur district. Cases were recruited from suspected or confirmed mucormycosis cases reported to district health authorities. Controls were household members who had COVID-19 but did not develop mucormycosis. Predisposing and treatment-related factors were analyzed. RESULTS: Analysis revealed significant associations between mucormycosis and diabetes mellitus (OR-10.8; CI-1.1-103.6) and corticosteroid use (OR-97.6; CI-3.2-2927.1). Factors such as humidifier use and mask usage did not show a significant association. CONCLUSION: Optimal use of oxygen and corticosteroids is crucial, particularly in diabetic COVID-19 patients, to prevent mucormycosis.

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