Abstract
Two potent ligands for adenosine receptors have been synthesized with non-exchangeable (3)H labeling to high specific activity. Both are adenosine antagonists, one a carboxylic acid congener, 1, and the other an amino congener, 2, and are structurally related to 1,3-dipropyl-8-phenylxanthine. The label was introduced at four positions in the n-propyl groups through catalytic reduction of 1,3-diallyl precursors. Due to favorable aqueous solubility. high potency and selectivity. these ligands are expected to be suitable for competitive binding assays and autoradiography.