Abstract
BACKGROUND: Magnetic resonance imaging (MRI) is a non-invasive technique that produces high-resolution images with excellent soft-tissue contrast, crucial for diagnosing various medical conditions. A key factor in MRI quality is the signal-to-noise ratio (SNR), which directly affects image clarity. To enhance SNR, passive inserts like high-permittivity dielectric pads or metamaterials are used between the tissue and coil. However, this method faces challenges such as detuning during radiofrequency (RF) transmission, which can interfere with the transmit field (B(1) (+)) and pose safety issues. PURPOSE: This study proposes a novel method to enhance SNR in MRI by using a non-closed lumped-element ladder resonator as a wireless insert. The aim is to optimize this ladder resonator through simulations and validate its performance in both phantom and in vivo MRI experiments. METHODS: The ladder resonator was designed and optimized through electromagnetic (EM) and RF circuit simulations using Ansys HFSS software. Various configurations (4, 6, 8, and 10 rungs) were tested. The optimized 8-rung resonator was then fabricated and evaluated against a single-loop resonator of the same size. MRI experiments were conducted using a 1.5T Siemens MRI scanner, assessing SNR improvements in both phantoms and volunteers. RESULTS: Simulation results indicated that the ladder resonator significantly improved local SNR compared to the single-loop resonator. The 8-rung ladder resonator provided the best performance. Experimental results corroborated these findings, with the 8-rung ladder resonator showing SNR improvements up to 4.7 times in human head images, compared to the standard head array alone. CONCLUSIONS: The study demonstrates that wireless ladder resonators can significantly enhance SNR in MRI, offering superior performance and more uniform sensitivity compared to traditional single-loop designs. The detunable feature of the ladder resonator ensures it does not interfere with the RF field, making it suitable for routine clinical use. The simplicity, cost-effectiveness, and compatibility with various MRI platforms underscore its potential for widespread clinical adoption.