Abstract
Introduction Dental caries is a prevalent oral health issue caused by the colonization of Streptococcus mutans in the oral cavity. Citrullus lanatus, commonly known as watermelon, is rich in bioactive compounds that possess antibacterial potential. In this study, we aimed to synthesize stannous chloride (SnCl(2)) nanoparticles (NPs) mediated by Citrullus lanatus extract and investigate their antibacterial effectiveness against Streptococcus mutans. Materials and method Stannous nanoparticles (SnNPs) synthesized by the green method were achieved by using the watermelon extract. Dilute stannous chloride solution was obtained by adding 0.45 g of stannous (Sn) chloride (Cl) powder to 60 mL of water, which was subjected to an orbital shaker with the watermelon extract. The nanoparticles obtained were subjected to characterization using antimicrobial testing, Fourier transform infrared (FTIR) spectroscopy, energy-dispersive X-ray (EDAX) analysis, and scanning electron microscopy (SEM). Agar well diffusion method was used against specific strains of S. aureus, S. mutans, and Escherichia coli. Results The novel nanoparticles demonstrated promising antibacterial activity against S. mutans providing 10 mm of inhibitory action. Conclusion Due to its abundance of naturally occurring bioactive chemicals and improved efficacy against S. mutans, watermelon extract can be utilized to create stannous nanoparticles as opposed to the use of toxic chemicals. They can also be employed as oral administration systems.