Abstract
Prairie voles (Microtus ochrogaster) are highly social rodents that have become a valuable animal model for studying social attachment, pair bonding, parental care, and the neurobiological mechanisms underlying social behavior. In recent years, due in part to the publication of the prairie vole genome and deeper mechanistic understanding of their social behavior, prairie voles have become a more popular research model, especially for translational research. However, generating reliable and reproducible findings requires effective colony management, including thoughtful breeding strategies, consistent husbandry practices, and clear documentation. In this paper, we describe the demographic history of and husbandry techniques employed in our prairie vole breeding colony at UC Davis from 2004 to 2020. Well-organized and transparent colony management allows for the preservation of informative behavioral traits in prairie voles and strengthens the impact of the prairie vole model across behavioral and biomedical science.