Abstract
(R)-[(18) F]MH.MZ ([(18) F]MH.MZ) is a promising positron emission tomography (PET) radiotracer for in vivo study of the 5-HT(2A) receptor. To facilitate clinical trials, a fully automated radiosynthesis procedure for [(18) F]MH.MZ was developed using commercially available materials on the iPhase Flexlab module. The overall synthesis time was 100 min with a radiochemical yield of 7 ± 0.9% (n = 3). The radiochemical purity was greater than 99% for [(18) F]MH.MZ with a molar activity of 361 ± 57 GBq/μmol (n = 3). The protocol described herein reliably provides [(18) F]MH.MZ that meets all relevant release criteria for a GMP radiopharmaceutical.